Results 1 – 8 Download Chimico farmaceutica savelli bruno and more books of the same author and others for free. a) F. SAVELLI, O. BRUNO: Analisi chimico Farmaceutica – Editore c) G.C. PORRETTA: Analisi quantitativa di composti farmaceutici – CISU. 5 a Ed. ETS Editrice, Pisa F. Savelli, O. Bruno. Analisi Chimico Farmaceutica – Piccin, Padova, A. Carta, M. G. Mamolo, F. Novelli.

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Scheda insegnamento — Laurea Magistrale in Farmacia

Salta alla navigazione Strumenti personali. Laurea Magistrale in Farmacia. Cerca nel sito solo nella sezione corrente. The final target is to set a rational basis for the study of the systematic medicinal chemistry.

Moreover, students will be engaged in some basic operations of organic chemistry, including purification and quality control of a reaction product. At the end, the student should be able to know and correctly use the basic tools present in a chemical analysis and research laboratory.

Prerequisites Knowledge of the topics of courses on Mathematics, Physics, General and Organic Chemistry Course programme Laboratory part General introduction to the analytical process and general methodologies in organic chemistry. Stoichiometric calculations, mass and volume measurements.


Acid-base, and redox equilibria titrations. Fundamental operations and general equipment in a chemical laboratory. Use of analytical balance. Preparation faramceutica solutions of common reagents and standardization with volumetric methodologies.

Electrical conductivity of solutions and laws of conductivity. Conductivity cells and conductimeter. Direct and indirect conductimetry. Direct analysis of a strong and a weak acid solution with conductimeter. Farmaxeutica operations in organic chemistry laboratory.

Filtration and recrystallization of an organic reaction product, with TLC control. Theorical basis of chromatographic separations, and TLC laboratory practice fxrmaceutica samples of different compounds mixtures. General Medicinal Chemistry part.

Interaction of drugs with receptors full, partial or inverse agonists, antagonistsenzymes reversible, irreversible, allosteric inhibitors and other biological targets. Selectivity toward different isozymes and receptor subtypes. How drugs bind with their target, polar and non-polar binding interactions.

Physicochemical properties of drugs and relation between biological ADME behavior and structural features. Drug distribution, acid-base properties. Lipophilicity definitions and lipophilicity scales.


Ionization rate, water solubility, definition and calculation of logP and logD. Main metabolic phases 1 and 2 transformations. Prodrugs and bioprecursors strategy.


The drug discovery process. Strategy and tactics in drug discovery. Target identification and validation, lead identification.

Analisi chimico farmaceutica – Francesco Savelli, Olga Bruno – Google Books

Lead compound optimisation, candidate compound selection, pharmacophore. Didactic methods Lectures for in fxrmaceutica 32 hours: Laboratory class for in total 24 hours, divided into 6 sessions. The work in the exercitation is done either individually or in pairs, depending on its difficulty. Learning assessment procedures Written examination and laboratory farmwceutica. If the written examination results positive, the final mark will be modified, but not averaged, by taking into consideration also the evaluation of the laboratory reports.

Farmacocinetica e Farmacodinamica su Basi Chimico-Fisiche. Manuale di chimica farmaceutica. I processi di scoperta dei farmaci. Chimica farmaceutica generale con laboratorio.

Dipartimento di Scienze della Vita e Biotecnologie Coordinatore: Via Luigi Borsari 46 – Ferrara Guarda la mappa.