La lipidosis hepática, o síndrome de hígado graso, es una enfermedad muy grave que ocurre exclusivamente en gatos de mediana edad y exceso de peso. Hepatic lipidosis (fatty liver disease) is a syndrome characterized by an accumulation of excessive amounts of lipid (fat) within the cells of the liver, abnormal bile. Koloffon-Tella, S., Trigo-Tavera, F. J., & Lopez, A. (). Lipidosis hepatica idiopatica felina / Idiopathic feline hepatic lipidosis. Patologia General Veterinaria .
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Fatty liver disease FLDalso known as hepatic steatosisis a condition where excess fat builds up in the liver. There are two types: The condition is also associated with other diseases that influence fat metabolism.
Fatty liver can develop into a fibrosis or a liver cancer. These pathologies can also affect non-obese people, who are then at a higher risk. Fatty liver FL is commonly associated with metabolic syndrome diabeteshypertensionobesityand dyslipidemiabut can also be due to any one of many causes: Fatty change represents the intracytoplasmatic accumulation of triglycerides neutral fats.
At the beginning, the hepatocytes present small fat vacuoles liposomes around the nucleus microvesicular fatty change. In this stage, liver cells are filled with multiple fat droplets that do not displace the centrally located nucleus.
In the late stages, the size of the vacuoles increases, pushing the nucleus to the periphery of the cell, giving characteristic signet ring appearance macrovesicular fatty change. These vesicles are well-delineated and optically “empty” because fats dissolve during tissue processing. Large vacuoles may coalesce and produce fatty cystswhich are irreversible lesions.
Macrovesicular steatosis is the most common form and is typically associated with alcoholdiabetesobesityand corticosteroids. Acute fatty liver of pregnancy and Reye’s syndrome are examples of severe liver disease caused by microvesicular fatty change. Defects in fatty acid metabolism are responsible for pathogenesis of FLD, which may be due to imbalance in energy consumption and its combustion, resulting in lipid storage, or can be a consequence of peripheral resistance to insulin, whereby the transport of fatty acids from adipose tissue to the liver is increased.
In addition, alcoholism is known to damage mitochondria and other cellular structures, further impairing cellular energy mechanism. On the other hand, non-alcoholic FLD may begin as excess of unmetabolised energy in liver cells. Hepatic steatosis is considered reversible and to some extent nonprogressive if the underlying cause is reduced or removed. Severe fatty liver is sometimes accompanied by inflammationa situation referred to as steatohepatitis. Progression to alcoholic steatohepatitis ASH or non-alcoholic steatohepatitis NASH depends on the persistence or severity of the inciting cause.
Pathological lesions in both conditions are similar.
Feline hepatic lipidosis – Wikipedia
However, the extent of inflammatory response varies widely and does not always correlate with degree of fat accumulation. Steatosis retention of lipid and onset of steatohepatitis may represent successive stages in FLD progression. Liver disease with extensive inflammation and a high degree of steatosis often progresses to more severe forms lipidksis the disease. Liver cell death and inflammatory responses lead to the activation of hepatic stellate cellswhich play a pivotal role in hepatic fibrosis.
The extent of fibrosis varies widely.
Translation of “lipidosis hepática” in English
Perisinusoidal fibrosis is most common, especially in adults, and predominates in zone 3 around the terminal hepatic veins. The progression to cirrhosis may be influenced by the amount of fat and degree of steatohepatitis and by a variety of other sensitizing factors.
In alcoholic FLD, the transition to cirrhosis related to continued alcohol consumption is well-documented, but the process involved in non-alcoholic FLD is less clear. Most individuals are asymptomatic and are usually discovered incidentally because of abnormal hepatuca function tests or hepatomegaly noted in unrelated medical conditions. ALT more than 2: Imaging studies hepatics often obtained during the evaluation process.
Ultrasonography reveals a “bright” liver with increased echogenicity. Medical imaging can aid in diagnosis of fatty liver; fatty livers have lower density than spleens on computed tomography CTand fat appears bright in T1-weighted magnetic resonance images MRIs.
Bepatica resonance elastographya variant of magnetic resonance imaging, is investigated as a non-invasive method to diagnose fibrosis progression.
The treatment of fatty liver depends on its cause, and, in general, treating the underlying cause will reverse the process of steatosis if implemented at an early stage. Fatty liver can be caused by different factors that are not all identified.
However, two known causes of fatty liver disease are an excess consumption of alcohol and a prolonged diet with a high proportion of calories coming from carbohydrates. In the case of long-term total parenteral nutrition induced fatty liver disease, choline has been shown to alleviate symptoms.
FLD is the most common cause of abnormal liver function tests in liipidosis United States. From Wikipedia, the free encyclopedia.
Lipidosis hepatica idiopatica felina / Idiopathic feline hepatic lipidosis
Fatty liver Synonyms Hepatic steatosis, simple fatty liver, simple steatosis Micrograph showing a fatty liver macrovesicular steatosisas seen in non-alcoholic fatty liver disease. Specialty Gastroenterology Fatty liver disease FLDalso known as hepatic steatosisis a condition where excess fat builds up in the liver. Retrieved 7 November Fatty liver disease and ljpidosis acid oxidation”. American Journal of Physiology. Gastrointestinal and Liver Physiology.
Clinical Gastroenterology and Hepatology. The New England Journal of Medicine. Expert Opinion on Drug Safety. Insights into associated conditions and underlying pathomechanisms”. Digestive and Liver Heepatica. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. Journal of Parenteral and Enteral Nutrition. Journal of the American Dietetic Association. Annals of Internal Medicine. Diseases of the digestive system primarily K20—K93— Coeliac Tropical sprue Blind loop lipidosia Small bowel bacterial overgrowth syndrome Whipple’s Short bowel syndrome Steatorrhea Milroy disease Bile acid malabsorption.
Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction: Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus.
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Fatty liver disease – Wikipedia
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